Archive for 'Resveratrol'

What is Resveratrol?

Posted on 01. Dec, 2010 by .

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Resveratrol (trans-Resveratrol) is a phytoalexin  (an antibiotic enzyme) produced by plants under stress as when attacked by fungi, disease-causing pathogens, adverse weather, insects or animals. It is a polyphenol with antioxidant properties as well; and thus protects the plants from UV radiation and other free radical damage.

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Resveratrol can also be chemically synthesized.

Seventy-two plant species are known to produce Resveratrol.

Some examples of plants or plant-based products and their Resveratrol average production capacity are:

  • Red wine – about 160 micrograms per ounce;
  • Boiled peanuts and red grapes – 75 micrograms per ounce;
  • Blueberries – 8 micrograms per ounce;
  • Japanese knotweed (Polygonum cuspidatum) – 6 micrograms per ounce; and
  • Bilberries – 3 micrograms per ounce.

Grapes, the most abundant natural source known, contain Resveratrol primarily in the skins, but also in the roots, seeds and vines depending on the cultivar (cultivated variety).

It is interesting to note that grape juice contains just half the amount of Resveratrol as red wine. Some speculate that the stress of the fermentation process and concurrent injuries to the skin induce increased production of the anti-stress enzyme.

When Resveratrol burst onto the anti-aging scene a few years ago, it was thought to be the key to the French Paradox.

Despite the fact that French men consume wine daily along with their high-fat diet, they have one-third the risk of heart attack of American men. However it is now believed that Resveratrol is only part of the answer.

It should be noted that Resveratrol is also a phytoestrogen (plant estrogen). The estrogenic properties of this chemical may play a role in the beneficial cardiovascular benefits of red wine by increasing blood levels of HDL, the healthy form of cholesterol.

On the other hand, pregnant or nursing women, women on hormone replacement therapy or those who have had estrogen-dependent cancer are advised to ask their health care professional before using resevratrol supplementation.

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Resveratrol Research Results

Posted on 07. Nov, 2010 by .

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What is Known about Resveratrol So Far Very few human studies on Resveratrol have been reported. Human dosage is an open question. Long term risks, if any, of Resveratrol supplementation have not been identified.

However what is already known about the multi-faceted anti-aging and anti-disease benefits of Resveratrol is exciting and has many people anxious to start Resveratrol supplementation.

Read the summaries of research results which follow. Then consult with your healthcare professional.

If you decide to give Resveratrol supplements a try, I recommend you buy from an established supplement company whose name you know and can rely on.

But I do see a huge amount of hype on the Internet about Resveratrol and a lot of brand new auto-ship plan companies and websites hawking Resveratrol.

Here are two excellent brand name formulations of Resveratrol that I can recommend. I’ll go more into their formulations at the end of later.

Life Extension
Various studies have shown that Resveratrol increases the life span of yeast cells, fruit flies, nematode worms, mice and Rhesus monkeys.

The mouse and monkey studies are especially interesting because they support an exciting theory about the mechanism of life extension in mammals.

“Previously the only proven mechanism of life extension for humans was extreme calorie restriction while avoiding malnutrition.” Not a very pleasant way to extend one’s life in my opinion.

Resveratrol may mimic the effects of calorie restriction by activating Sirtuin 1, an enzyme that regulates gene activity and cellular life spans – suppressing excess gene activity and boosting antioxidant activity (Lagouge M. et al., Cell, December 2006).

Sirt-1 acts like a voltage regulator, protecting the body’s “electrical equipment” from power surges and shorts which shorten cell life.

In other studies carried out by Harvard Medical School and The National Institute on Aging (Sinclair D. et al., Harvard Medical Office of Public Affairs, November 2006), it was demonstrated that, not only did mice on Resveratrol live longer, but they also lived stronger as measured by their performance on rotorods (imagine walking on a log rolling in water).

So how much Resveratrol does one need to take to live longer and stronger?

We really don’t know yet since there have been no published reports of studies on humans.

The lab mice in the study highlighted on 60 Minutes were given massive doses for their body weight (22 mg/kg).

Even adjusting the dose for the slower human metabolism, a 180 pound human might need 4800 mg a day.

However another study (Barger J.L. et al., PubMedCentral, June 2008) achieved similar anti-aging benefits with mice using a dose of 4.9 mg/kg which would mathematically equate to a more reasonable human dose of 1000 mg a day.

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How Resveratrol Prevent or Cure for Cancer

Posted on 07. Nov, 2010 by .

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The evidence for Resveratrol as a cancer preventive or curative agent is very mixed. As noted above, Resveratrol is a phytoestrogen and could actually promote the growth of estrogen-dependent tumors.

In vitro, Resveratrol has been shown to interfere with all three stages of cancer development – initiation, promotion and progression. Successful in vitro studies have been reported for many types of cancer cells: colon, esophageal, gastric, leukemia, pancreatic, prostate, skin and even breast.

If Resveratrol does develop into a cancer treatment, it is unlikely to be in pill form. The dosage would have to be massive (Boocock D.J. et al., Cancer Epidemiology, June 2007).

As well, pills would be an inefficient way to deliver the drug and would increase potential for negative side effects on healthy organs.

In animal models, topical application for skin cancer (Jang M. et al., Science, February 1997) and intra-peritoneal injection for gastrointestinal cancers (Fontecave M. et al., FEBS Letters, Vol. 421, 1998) have slowed and even prevented cancer growth.

As a cancer prophylactic, the news for oral Resveratrol is a bit better.

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Resveratrol supplementation in small doses (1or 2 mg/kg) reduced the number and size of esophageal tumors (Li Z.G. et al., Carcinogenesis, September 2002) and prevented the development of colon and intestinal tumors (Fontcave ibid.) in mice which were injected with specific cancer causing agents.

The equivalent prophylactic dose for a 180 pound human would be 220 or 440 mg a day.

Protection against Alzheimer’s
A joint study carried out at the Weill Medical College of Cornell University and the New York Medical College at Valhalla (Karuppagounder S.S. et al., Neurochemistry International, February 2009) supports the theory that Resveratrol (or other chemo-protective agents) may delay or mitigate the onset of neurodegenerative diseases like Alzheimer’s.

Mice fed a “clinically feasible oral dose” of Resveratrol for 45 days had a significant reduction in amyloid plaque formation which can lead to Alzheimer’s and other forms of dementia.

Insulin Regulation and Complications of Diabetes
Diabetes is characterized by insulin resistance which allows toxic levels of glucose to build up in the system.

Poorly managed, this build-up can cause disorientation, insulin shock and even death.

Sugar (glucose) is pro-inflammatory. Over time, high levels of sugar in the bloodstream can lead to circulatory damage (and in the extreme, loss of limbs), diabetic neuropathy (nerve pain) and even blindness.

Resveratrol shows promise for the management of diabetes and avoidance of all the above complications.

As noted in the section on Life Extension, Resveratrol stimulates the activity of Sirt-1 to promote a longer and stronger life. This marvelous enzyme (Sirt-1) has also been shown to improve insulin sensitivity in diabetic mice.

Initial mouse model studies of Resveratrol and diabetes used very large oral doses to demonstrate benefit.

Scientists are homing in on the lowest possible dose. A recent study showed increased insulin sensitivity at a dose of just 2.5 mg/kg of mouse body weight (Sun et al., Cell Metabolism, October 2007). Mathematically that converts to a very reasonable daily dose of 550 mg for a 180-pound human.

Another mouse model study demonstrated that Resveratrol is a potent neuroprotective agent against diabetic oxidative damage. Even in the presence of high blood sugar levels. 10 mg/kg injected intraperiteonally prevented oxidative damage to the central nervous system (Ates O. et al., Journal of Clinical Neuroscience, March 2007).

Finally a mouse model study into Resveratrol’s effect on diabetic neuropathy showed that oral doses as low as 5 mg/kg significantly reduced nerve pain. The researchers also tested 10 and 20 mg doses and found that Resveratrol reduced pro-inflammatory tumor necrosis factor and excess nitric oxide in a dose-dependant manner (Sharma S. et al., Fundamental and Clinical Pharmacology, February 2007).

The equivalent daily dose to manage diabetic pain for a 180-pound human would be between 1000 and 4400 mg. However, there have not yet been any reported human trial results.

No Resveratrol studies on humans have yet been reported. If you are ill, suspect you have a disease or are under a doctor’s care, do not take Resveratrol before consulting a qualified physician.

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Resveratrol and Disease

Posted on 07. Nov, 2010 by .

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Resveratrol Shows Promise as a Disease Fighter

No Resveratrol studies on humans have yet been reported. If you are ill, suspect you have a disease or are under a doctor’s care, do not take Resveratrol before consulting a qualified physician.

Prevention of Coronary Heart Disease

Resveratrol may help prevent heart disease in two ways: as an antioxidant to prevent free radical damage to the circulatory system; and as an agent to prevent platelets from sticking together and forming blood clots.

Resveratrol is a universal antioxidant (able to protect against oxidation in both water and fat-based portions of cells).

Though that is an important benefit, Resveratrol is not as potent an antioxidant as others contained in red wine such as epicatechin and quercetin.

In addition, it is generally better to have a cocktail of antioxidants to protect all parts of the cells and to protect against all sorts of oxidative stress.

Reduced platelet aggregation has been demonstrated in several in vitro studies of Resveratrol (Rotondo S. at al., British Journal of Pharmacology, April 1998).

Trans-Resveratrol , the most biologically active form of Resveratrol, was shown to reduce the risk of heart attack in two ways. It interferes with the release of inflammatory compounds and it decreases the formation of sticky platelets and therefore blood clots.

Resveratrol’s anti-platelet and antioxidant properties have, thus far, been demonstrated in vitro. Studies in animals and humans are needed.

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What are Resveratrol Supplement Vitamins?

Posted on 07. Nov, 2010 by .

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One of the best ways to benefit from resveratrol, is to take it in pill form. These resveratrol supplement vitamins posses the power to heal free radicals and repair damage to the body on a cellular level. These free radicals cause major damage to arteries and contribute to the hardening process that blocks the flow of blood to the the organs. With the advent of highly concentrated resveratrol supplements, people are now able to benefit from the effects of red wine without the alcohol component.

4377056429 1a20f974ce m What are Resveratrol Supplement Vitamins?Since resveratrol was featured on 60 minutes as being the natural “fountain of youth”, many people have turned to resveratrol capsule vitamins to provide them with a safe concentrated daily dose. By incorporating a daily dose of resveratrol pills in your diet, resveratrol health benefits include reducing your risk of cardiovascular disease, increase your energy, repair cell damage and live a longer, healthier life.

By unlocking the secrets of the health benefits of red wine, scientists have been able to synthesize the most important natural component which is derived from the skin of the red grape. Resveratrol is that wonder drug. Since it’s 100% natural, it’s very safe to use. Recent experiments performed on mice and other animals using pure resveratrol vitamins have shown an increase in their life expectancy along the lines of what a person utilizing calorie restriction would see.

Resveratrol supplement vitamins offer a low cost benefit to your health. I have seen several variations of the vitamins take the form of resveratrol pills, resveratrol liquid or even resveratrol lozenges. I find that resveratrol pills offer the simplest and most convenient form to take. So if your wanting to keep your cells healthy, I highly recommend taking resveratrol supplements to prolong your life and limit the damage to your body.

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