Archive for 'Alanine'

Alanine amino acid

Posted on 11. Nov, 2010 by .


Alanine is a non-essential amino acid and is used by the body to build protein and was first isolated in 1879. The alpha-carbon in alanine is substituted with a levorotatory (l)-methyl group, making it one of the simplest amino acids with respect to molecular structure and is one of the most widely used in protein construction

Alanine is main function seems to be the metabolism of tryptophan and pyridoxine. Alanine is located in prostate fluid, and may play an important role in prostate health. Good sources of alanine are meat, poultry, eggs, dairy products, and fish. High levels of alanine along with low levels of tyrosine and phenylalanine have been associated with the Epstein-Barr virus and chronic fatigue syndrome. Low levels have been found in patients with hypoglycemia, diabetes, and alcohol induced hepatitis.

Alanine is required for

It is required for the metabolism of glucose and tryptophan and beta-alanine is a constituent of vitamin B5 (pantothenic acid) as well as coenzyme A. It has also demonstrated a cholesterol-reducing effect in rats.

People suffering from Epstein Barr (also sometimes referred to as glandular fever) as well as chronic fatigue syndrome, have been linked to excessively high levels of alanine while having low levels of tyrosine and phenylalanine.

What is Beta Alanine?

Beta alanine is an amino acid which is scientifically proven to reduce fatigue. It works via a chemical known as carnosine — beta alanine is the limiting factor in human carnosine levels.

Beta-alanine (BA), a dietary supplement widely used by athletes and body builders, has been proven to increase the fitness levels of a group of elderly men and women. The research, published in Journal of the International Society of Sports Nutrition, suggests that BA supplementation improves muscle endurance in the elderly.

The research was carried out by Jeffrey Stout, PhD from the University of Oklahoma, USA, and a team of colleagues. According to Dr. Stout, “This could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.”

BA is an amino acid that, together with histidine, forms the dipeptide carnosine. Carnosine is found in muscle tissue and makes an important contribution to the maintenance of intracellular pH, which is vital for normal muscle function during intense exercise. An increased intake of BA significantly raises muscle carnosine levels.

In this double-blind, randomized controlled trial, 26 elderly men and women were given a 90-day course of BA supplementation or placebo pills. Their fitness levels were tested before and after the course. In the treatment group, 67% of the subjects showed an improvement in their fitness levels, compared to 21.5% of the people receiving the placebo treatment.

The researchers write, “Our data suggest that 90 days of BA supplementation increases physical working capacity in elderly men and women. These findings are clinically significant, as a decrease in functional capacity to perform daily living tasks has been associated with an increase in mortality, primarily due to increased risk of falls.”

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